Cytokine responses in porcine respiratory coronavirus - infected pigs 1 treated with corticosteroids as a model for Severe Acute Respiratory 2 Syndrome 3 4 Running title : Corticosteroid treatment of respiratory
نویسندگان
چکیده
Corresponding author: Mailing address: Food Animal Health Research Program, 14 Ohio Agricultural Research and Development Center, The Ohio State University, 15 1680 Madison Ave., Wooster, OH 44691. Phone: (330)263-3744. Fax: (330)26316 3677. E-mail: [email protected] 17 18 19 Abstract word counts: 190 20 Total word counts: 5,002 (References and figure legends not included) 21 CC EP TE D Copyright © 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Virol. doi:10.1128/JVI.02190-07 JVI Accepts, published online ahead of print on 20 February 2008
منابع مشابه
Cytokine responses in porcine respiratory coronavirus-infected pigs treated with corticosteroids as a model for severe acute respiratory syndrome.
The effectiveness and potential immunosuppressive effects of anti-inflammatory glucocorticoids in the lungs of severe acute respiratory syndrome (SARS) patients are undefined. We treated porcine respiratory coronavirus (PRCV)-infected conventional pigs with the corticosteroid dexamethasone (DEX) as a model for SARS. Innate and Th1 cytokines in bronchoalveolar lavage (BAL) and serum were elevate...
متن کاملAltered pathogenesis of porcine respiratory coronavirus in pigs due to immunosuppressive effects of dexamethasone: implications for corticosteroid use in treatment of severe acute respiratory syndrome coronavirus.
The pathogenesis and optimal treatments for severe acute respiratory syndrome (SARS) are unclear, although corticosteroids were used to reduce lung and systemic inflammation. Because the pulmonary pathology of porcine respiratory coronavirus (PRCV) in pigs resembles SARS, we used PRCV as a model to clarify the effects of the corticosteroid dexamethasone (DEX) on coronavirus (CoV)-induced pneumo...
متن کاملGastrointestinal Manifestations in Patients Infected with SARS-CoV-2
Coronavirus disease 2019, caused by severe acute respiratory syndrome coronavirus 2, has recently become the number one problem affecting global health. Coronavirus disease 2019 is principally recognized by its respiratory manifestations; however, recent studies have shown an increasing number of patients with gastrointestinal complaints like diarrhea, nausea, vomiting, and abdominal discomfort...
متن کاملCoinfection of pigs with porcine respiratory coronavirus and Bordetella bronchiseptica.
Coinfection with two or more pathogens is a common occurrence in respiratory diseases of most species. The manner in which multiple pathogens interact is not always straightforward, however. Bordetella bronchiseptica and porcine respiratory coronavirus (PRCV) are respiratory pathogens of pigs whose relatives, B. pertussis and the SARS virus, cause respiratory disease in humans. In an initial ex...
متن کاملEar necrosis syndrome in weaning pigs associated with PCV2 infection: A case report
Porcine necrotic ear syndrome (PNES) in pigs has been reported as an increasing health problem in many countries with intensive pig farming. The etiology of this disease is complex and the presumed triggering factors can be divided into infectious and non-infectious agents. The present report describes a case of Porcine Circovirus type 2 (PCV2), infection associated with lesions of PNES at the ...
متن کامل